The NOBEL PRIZE in MEDICINE and the SCIENCE
“More than any other single factor, Nitric Oxide may be the key to living a longer, healthier life.”
Louise J. Ignarro
Nobel Prize in Medicine Laureate
“I am convinced that Nitric Oxide can age-proof your cardiovascular system, keeping it much fitter than your chronological age would indicate. Repairing the damage wrought by cardiovascular disease without risky and often ineffective surgery had long been considered impossible. I was awarded the Nobel Prize in Medicine for making that thinking obsolete.
Now we know we can reverse cardiovascular impairment naturally—with the body's internally manufactured ‘wonder drug’, Nitric Oxide.
Your body has four essential bodily processes: vascular tone, coagulation, inflammation and oxidation. Nitric Oxide therapy can make a lifesaving difference to your health by enhancing the positive and eradicating the negative in each of them.”
[Louise J. Ignarro]
In 1998, three scientists were jointly awarded a NOBEL PRIZE in MEDICINE for discovering L-arginine as a singling molecule for the production of Nitric Oxide in the body—effectively targeting the underlying cause of most Cardiovascular Disease.
Since then there have been hundreds, perhaps thousands, of research trials and papers written supporting it.
It is also now known that Nitric Oxide survives only moments, from seconds to a few minutes, once in the bloodstream, so to ensure an effective therapeutic result there needs to be a significant amount of L-arginine taken.
Dr Murad being awarded his Nobel Prize in Medicine, 1998
The world’s most published researcher on Nitric Oxide, world-wide, is German scientist, Dr Rainer Böger (pictured to the right), whose research discovered how to ‘turbo-charge’ the level and longevity of Nitric Oxide. His findings show that combining medicinal grade L-arginine and L-citrulline at a particular ratio extends the level and longevity of the Nitric Oxide from only a few minutes to over twelve hours.
This is important because instead of needing many doses per day to maintain an effective therapeutic level of Nitric Oxide in the blood (something you’ll not likely hear about from suppliers), with a sufficiently high quality product (there is none as high as Nitric Oxide Infusion) only two doses per day are required (one in the morning, one in the evening), so significant and sometimes dramatic results, as well as cost/savings, can achieved.
LEADING SCIENTISTS AGREE
Renowned Cardiologist & Endocrinologist, Dr Joe Pendergast
Dr Joe Pendergast is renowned for his significant results using Nitric Oxide and cardiovascular health over the last 30 years, long before the Nobel Prize shone the spotlight on the humble amino acid.
He is perhaps one of the world’s most recognised researchers and practitioners in Nitric Oxide and its role in reversing Cardiovascular Disease.
“I believe that Nitric Oxide is the single most important discovery in preventing heart disease that I have seen during the course of my medical career. Of course there are many treatments for heart disease, but I haven't seen anything as effective.
We cannot ignore the power of Nitric Oxide anymore. Heart Disease is the number one killer for both men and women. The main factors are arteriosclerosis—hardening of the arteries, and atherosclerosis—buildup on the arterial lining. Nitric Oxide reverses both problems.”
Dr. John Cooke, Director of Vascular Medicine at Stanford University, Author of the book, “The Cardiovascular Cure”
Let me “...introduce you to the magic inside your blood vessels. It comes in the shape of a molecule, one of the simplest molecules found in nature. This molecule is Nitric Oxide, or N.O., a substance so powerful that it can actually protect you from heart attack and stroke.
N.O. is your body's own built-in, natural protection against heart disease."
Dr. Robert Fried, Ph.D and Woodson Merrell, M.D. Co-authors: “The Arginine Solution”
"In the field of medicine and health, the discovery that the amino acid L-arginine may be a ‘MAGIC BULLET' for the cardiovascular system it is one of the revolutions of our time.
Now, as the evidence mounts, including research that won the NOBEL PRIZE in MEDICINE, more and more scientists and doctors see the extraordinary health benefits of increasing arginine Intake.
A virtual arterial cleanser, arginine helps eliminate blockage and maintain blood flow.”
Dr. Jonathan S. Stamler, Professor of Medicine, Duke University Medical Center
"It does everything, everywhere. You cannot name a major cellular response or physiological effect in which [Nitric Oxide) is not implicated.
It's involved in complex behavioral changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, function of blood cells, the immune system, even how fingers and arms move."
NITRIC OXIDE and VASCULAR DISEASE
Journal of Vascular Surgery Vol 40 Issue 1 pp 187-193
Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability.
The objective was to investigate the acute effects of a combination of oral L-citrulline and L-arginine on plasma L-arginine and NO levels, as well as on blood circulation.
The results show that a combination of oral L-citrulline and L-arginine effectively and rapidly augments NO-dependent responses at the acute stage. This approach may have clinical utility for the regulation of cardiovascular function in humans.
Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with pre-capillary pulmonary hypertension.
Oral supplementation of L-arginine significantly increased plasma L-citrulline, which indicated enhancement of NO production. Results suggest that oral supplementation of L-arginine may have beneficial effects on hemodynamics and exercise capacity in patients with pre-capillary pulmonary hypertension.
Endothelial Dysfunction: Cardiovascular Risk Factors
Endothelial dysfunction is a well established response to cardiovascular risk factors and precedes the development of atherosclerosis. Endothelial dysfunction is involved in lesion formation by the promotion of both the early and late mechanisms of atherosclerosis including up-regulation of adhesion molecules, increased chemokine secretion and leukocyte adherence, increased cell permeability, enhanced low-density lipoprotein oxidation, platelet activation, cytokine elaboration, and vascular smooth muscle cell proliferation and migration. Endothelial dysfunction is a term that covers diminished production/availability of nitric oxide and/or an imbalance in the relative contribution of endothelium-derived relaxing and contracting factors. Also, when cardiovascular risk factors are treated the endothelial dysfunction is reversed and it is an independent predictor of cardiac events. We review the literature concerning endothelial dysfunction in regard to its pathogenesis, treatment, and outcome.
Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease.
Restoring NO formation and endothelium-dependent vasodilation by L-arginine improves the clinical symptoms of intermittent claudication in patients with peripheral arterial occlusive disease.
Nitric oxide bioavailability affects cardiovascular regulation dependent on cardiac nerve status.
These results validate earlier claims that reduced NO bioavailability imposes an upper limit on myocardial blood flow regulation and its transmural distribution.
Hyperaggregability and impaired nitric oxide production in platelets from postmenopausal women.
Postmenopausal women present increased platelet reactivity, which may be due to a reduction in intraplatelet nitric oxide synthesis. Platelet hyperaggregability is known to be associated with arterial and venous thromboembolic event; therefore, it may contribute to the heightened risk of cardiovascular adverse events in this population.
L-Arginine and its metabolites in kidney and cardiovascular disease.
A large number of studies have been performed in experimental models of kidney disease with sometimes conflicting results, which underlie the complexity of Arg metabolism and our incomplete knowledge of all the mechanisms involved, moreover several lines of evidence demonstrate the role of L-arginine metabolites in cardiovascular disease and that L-arginine administration role in reversing endothelial dysfunction, which is the leading cause of cardiovascular diseases, such as hypertension and atherosclerosis.
Investigating the cardio-protective abilities of supplemental
L-arginine on parameters of endothelial function in a hypercholesterolemic animal model.
This study investigated the ability of the highly intriguing amino acid L-arginine to influence endothelial function. Its therapeutic potential is also compared to that of known cardiovascular medications, namely nitroglycerin [a nitric oxide (NO) donor] and enalapril [an angiotensin-converting enzyme (ACE) inhibitor].
Based on the results of this study, L-arginine appears to be a novel cardio-protective agent, illustrated by its ability to ameliorate the deleterious effects of hypercholesterolemia on endothelial function, in a manner comparable to, and sometimes more potent than, commonly used cardiovascular medications.